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Post-test probability (Bayes’ theorem)

Converts a disease’s pretest probability to probability after a test result using that result’s likelihood ratio.

Arithmetic checks are available. Independent clinical review is pending. Inclusion in the catalogue does not constitute clinical validation.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

Bayes odds: Fagan 1975; pretest odds×LR, posttest conversion; Deeks–Altman 2004 likelihood ratios

Pre-test probability must represent the population and clinical context assessed; the likelihood ratio must correspond to the test and result category. Probability and odds are different quantities: updating multiplies odds by the likelihood ratio and only then converts back to probability. Predictive values vary with prevalence and do not transfer automatically between studies and services. The calculation updates an estimate; it does not independently confirm or exclude a disease.

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% · range 0.1–99.9
Numeric value · range 0.001–1000

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Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

  • Pretest probability (prevalence or clinical estimate) · %
  • Likelihood ratio of the result (LR+ if positive, LR− if negative)

3/3 reference cases checked. Numerical tests are not clinical validation.

Relationship with cancer research

Support for research — context required

A general method for post-test probability. It requires pre-test probability and test performance applicable to the population; it is not a cancer detector.

Applications: Early detection and risk assessment · Clinical trials and methods

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