NAFLD Fibrosis Score (NFS)
A noninvasive score developed for nonalcoholic fatty liver disease (now MASLD), separating low and high probability of advanced fibrosis (F3–F4).
Calculate with transparency
Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.
Preparing the form…
- Check the method
- Enter the data
- Check the result
Method · Limits of application
NFS by Angulo et al. (2007), six variables; the original formula and cutoffs were checked in Table 1 of McPherson et al. (2017). This implementation uses the lower cutoff of 0.12 at age ≥65 years; the upper cutoff remains 0.676.
The original model was derived from biopsy-confirmed NAFLD, not from every population now termed MASLD. McPherson (2017) assessed European specialist clinics, excluded other liver diseases and excessive alcohol consumption, and found poor performance in people aged ≤35 years. Figure 4 and its caption differ at the age boundaries of 35 and 65; these exact ages have not been clinically adjudicated here. The lower cutoff of 0.12 at age ≥65 is the declared policy of this implementation. Platelets in ×10³/mm³ are numerically equivalent to ×10⁹/L; albumin must be in g/dL. The score is displayed to three decimal places; classification uses strict cutoffs without rounding the score. Intermediate values are inconclusive; NFS alone does not confirm F3–F4. Independent professional clinical and language review has not been performed.
Conditions of use
Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.
Documented parameters
- Age · years
- BMI · kg/m²
- Impaired fasting glucose or diabetes
- Aspartate aminotransferase (AST) · U/L
- Alanine aminotransferase (ALT) · U/L
- Platelets · × 10³/mm³
- Albumin · g/dL
3/3 reference cases checked. Numerical tests are not clinical validation.
Relationship with cancer research
General context — relationship to be defined
A resource for general clinical contexts. This edition does not assign a specific oncological relationship; selecting it for a study requires a justified question, population and purpose.