PUBLIC LIBRARY / CALCULATOR

Calculated LDL cholesterol

Calculates LDL-C using Friedewald and Sampson (NIH) and non-HDL cholesterol from the lipid profile.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

Friedewald 1972 TG<400 and Sampson NIH 2020 TG≤800; coefficients 0.948/0.971/8.56/2140/16100/9.44

Sampson 2020 assessed LDL-cholesterol estimation up to triglycerides of 800 mg/dL; people with type III hyperlipidemia were excluded. The development sample had a high frequency of hypertriglyceridemia, with external validation in other populations. The formula estimates, rather than directly measures, LDL cholesterol. Its limits must not be transferred to the Friedewald formula; preserve the selected variant, unit and triglyceride domain stated for each method.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Total cholesterol · mg/dL
HDL cholesterol · mg/dL
Triglycerides · mg/dL

2/2 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

Non-HDL-C = TC − HDL
Friedewald: LDL = TC − HDL − TG ÷ 5 (valid with TG < 400 mg/dL)
Sampson (NIH 2020): LDL = TC/0.948 − HDL/0.971 − (TG/8.56 + TG × non-HDL/2140 − TG²/16100) − 9.44 (valid up to TG 800 mg/dL)

References

Identifier: ldl-calculado

Original clinical content: Brazilian Portuguese.

Method version

Friedewald 1972 TG<400 and Sampson NIH 2020 TG≤800; coefficients 0.948/0.971/8.56/2140/16100/9.44

ldl-calculado@native-2026-10-03+020feed42a84

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (2)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Total cholesterol: 200 mg/dL
HDL cholesterol: 50 mg/dL
Triglycerides: 150 mg/dL

{
  "ct": 200,
  "hdl": 50,
  "tg": 150
}

Expected result

{
  "friedewald": 120,
  "sampson": 123.4,
  "nonhdl": 150
}

Actual result

{
  "friedewald": 120,
  "sampson": 123.39729061516445,
  "nonhdl": 150
}

Case 2

reference-002

Inputs

Total cholesterol: 250 mg/dL
HDL cholesterol: 40 mg/dL
Triglycerides: 450 mg/dL

{
  "ct": 250,
  "hdl": 40,
  "tg": 450
}

Expected result

{
  "nonhdl": 210
}

Actual result

{
  "friedewald": 120,
  "sampson": 128.9271032615229,
  "nonhdl": 210
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

General context — relationship to be defined

A resource for general clinical contexts. This edition does not assign a specific oncological relationship; selecting it for a study requires a justified question, population and purpose.