PUBLIC LIBRARY / CALCULATOR

Sampson 2021 · sdLDL-C estimate

Lipid subfraction estimate; not equivalent to direct measurement. In direct mode enter LDL-C; in panel mode enter total cholesterol and HDL-C. Independent clinical review has not been performed.

Check the method
Enter the data
Review the result

Estimate sdLDL-C in ELUCENIA

Sampson 2021 equation. Use measured LDL-C or estimate LDL-C from the lipid panel with Sampson–NIH 2020. Calculations run in ELUCENIA; do not enter patient identifiers.

Sources and documentation

Method version

Sampson 2021; optional LDL-C calculation by Sampson–NIH 2020

Formula and criteria

sdLDL-C = LDL-C − (1.43 × LDL-C − 0.14 × ln(TG) × LDL-C − 8.99), in mg/dL. In panel mode, LDL-C = TC/0.948 − HDL-C/0.971 − (TG/8.56 + TG × (TC − HDL-C)/2140 − TG²/16100) − 9.44. TC, HDL-C and TG in mg/dL. ln denotes the natural logarithm.

Population and limitations

Lipid subfraction estimate; not equivalent to direct measurement. In direct mode enter LDL-C; in panel mode enter total cholesterol and HDL-C. Independent clinical review has not been performed.

Synthetic cases checked (1)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

{
  "tcMgDl": "200",
  "hdlMgDl": "50",
  "triglyceridesMgDl": "150"
}

Expected result

{
  "value": 42.5,
  "unit": "mg/dL"
}

Actual result

{
  "value": 42.5,
  "unit": "mg/dL"
}

References

Identifier: jas-sdldl-sampson

Checking formulas and synthetic cases does not constitute clinical validation.

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

General context — relationship to be defined

A resource for general clinical contexts. This edition does not assign a specific oncological relationship; selecting it for a study requires a justified question, population and purpose.