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ISTH overt DIC score

Diagnoses overt disseminated intravascular coagulation using simple tests in patients with an underlying disease known to cause DIC.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

ISTH/Taylor 2001: overt DIC, platelets/FDP/PT/fibrinogen, total 0–8

Apply in the context of an underlying disease compatible with DIC, combining clinical and laboratory data. The process is dynamic and requires repeated assessment. A score alone does not establish the diagnosis; accuracy varies with population and score stratum.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Platelets
Fibrin marker (D-dimer or fibrin degradation products)
Prothrombin time prolongation
Fibrinogen

3/3 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

Platelets > 100 thousand 0, 50–100 thousand 1, < 50 thousand 2 · D-dimer/FDP no rise 0, moderate 2, marked 3 · PT prolongation < 3 s 0, 3–6 s 1, > 6 s 2 · fibrinogen ≥ 1 g/L 0, < 1 g/L 1. Maximum: 8.

Prerequisite: DIC-associated underlying disease (sepsis, trauma, cancer, obstetric complication, etc.).

References

Identifier: isth-cid

Original clinical content: Brazilian Portuguese.

Method version

ISTH/Taylor 2001: overt DIC, platelets/FDP/PT/fibrinogen, total 0–8

isth-cid@native-2026-10-05+7b2cc692fc33

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (3)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Platelets: 50,000 to 100,000/µL
Fibrin marker (D-dimer or fibrin degradation products): Moderate increase
Prothrombin time prolongation: < 3 s
Fibrinogen: ≥ 1 g/L

{
  "plaq": "1",
  "dd": "2",
  "tp": "0",
  "fib": "0"
}

Expected result

{
  "score": 3,
  "level": "mid"
}

Actual result

{
  "score": 3
}

Case 2

reference-002

Inputs

Platelets: < 50,000/µL
Fibrin marker (D-dimer or fibrin degradation products): Moderate increase
Prothrombin time prolongation: 3 to 6 s
Fibrinogen: ≥ 1 g/L

{
  "plaq": "2",
  "dd": "2",
  "tp": "1",
  "fib": "0"
}

Expected result

{
  "score": 5,
  "level": "high"
}

Actual result

{
  "score": 5
}

Case 3

reference-003

Inputs

Platelets: < 50,000/µL
Fibrin marker (D-dimer or fibrin degradation products): Marked increase
Prothrombin time prolongation: > 6 s
Fibrinogen: < 1 g/L (100 mg/dL)

{
  "plaq": "2",
  "dd": "3",
  "tp": "2",
  "fib": "1"
}

Expected result

{
  "score": 8,
  "level": "high"
}

Actual result

{
  "score": 8
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

README

Local installation

Code license: Apache-2.0

Guidelines and conditions

This repository’s license applies to the code. Third-party instruments, questionnaires, data and models remain subject to their owners’ conditions.

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

General context — relationship to be defined

A resource for general clinical contexts. This edition does not assign a specific oncological relationship; selecting it for a study requires a justified question, population and purpose.