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Charlson Comorbidity Index

Quantifies comorbidity burden and long-term prognosis, used for study risk adjustment and decisions about screening and aggressive treatment.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

CCI/Charlson 1987; age-adjusted Charlson 1994; age points 50–59/60–69/70–79/≥80; local survival estimate

Identify whether the index includes age adjustment. It is a prognostic comorbidity measure studied in defined cohorts and time horizons, not a universal prediction. The local survival equation requires its own checking and calibration; a bibliographic reference does not establish its individual performance.

Required fields: 0/17 completed

Complete all required fields. Optional fields are marked.

Age required

Previous myocardial infarction required

Congestive heart failure required

Peripheral arterial disease (or aortic aneurysm ≥ 6 cm) required

Cerebrovascular disease (stroke with mild residual deficit or TIA) required

Dementia required

Chronic pulmonary disease required

Connective tissue disease (SLE, polymyositis, rheumatoid arthritis, polymyalgia) required

Peptic ulcer disease required

Liver disease required

Diabetes mellitus required

Hemiplegia required

Moderate or severe renal disease (creatinine > 3 mg/dL, dialysis or transplant) required

Solid tumor required

Leukemia required

Lymphoma required

AIDS (not HIV positivity alone) required

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Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Age
Previous myocardial infarction
Congestive heart failure
Peripheral arterial disease (or aortic aneurysm ≥ 6 cm)
Cerebrovascular disease (stroke with mild residual deficit or TIA)
Dementia
Chronic pulmonary disease
Connective tissue disease (SLE, polymyositis, rheumatoid arthritis, polymyalgia)
Peptic ulcer disease
Liver disease
Diabetes mellitus
Hemiplegia
Moderate or severe renal disease (creatinine > 3 mg/dL, dialysis or transplant)
Solid tumor
Leukemia
Lymphoma
AIDS (not HIV positivity alone)

4/4 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

1 point: myocardial infarction, heart failure, peripheral arterial disease, cerebrovascular disease, dementia, chronic lung disease, connective-tissue disease, peptic ulcer, mild liver disease, diabetes without end-organ damage. 2 points: hemiplegia, moderate/severe kidney disease, diabetes with end-organ damage, solid tumour, leukaemia, lymphoma. 3 points: moderate/severe liver disease. 6 points: metastatic tumour, AIDS.

Age adjustment (Charlson 1994): 1 point per decade from age 50 (50–59=1; 60–69=2; 70–79=3; ≥80=4).

Estimated 10-year survival = 0.983^{e^{(0.9 × index)}} × 100%.

References

Identifier: indice-de-charlson

Original clinical content: Brazilian Portuguese.

Method version

CCI/Charlson 1987; age-adjusted Charlson 1994; age points 50–59/60–69/70–79/≥80; local survival estimate

indice-de-charlson@native-2026-10-03+9faf773ca651

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (4)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Age: < 50
Liver disease: No
Diabetes mellitus: No
Solid tumor: No
Previous myocardial infarction: No
Congestive heart failure: No
Peripheral arterial disease (or aortic aneurysm ≥ 6 cm): No
Cerebrovascular disease (stroke with mild residual deficit or TIA): No
Dementia: No
Chronic pulmonary disease: No
Connective tissue disease (SLE, polymyositis, rheumatoid arthritis, polymyalgia): No
Peptic ulcer disease: No
Hemiplegia: No
Moderate or severe renal disease (creatinine > 3 mg/dL, dialysis or transplant): No
Leukemia: No
Lymphoma: No
AIDS (not HIV positivity alone): No

{
  "idade": "0",
  "figado": "0",
  "dm": "0",
  "tumor": "0",
  "iam": false,
  "icc": false,
  "dap": false,
  "avc": false,
  "demencia": false,
  "dpoc": false,
  "colageno": false,
  "ulcera": false,
  "hemiplegia": false,
  "renal": false,
  "leucemia": false,
  "linfoma": false,
  "aids": false
}

Expected result

{
  "sobrevida": 98.3
}

Actual result

{
  "score": 0,
  "cci": 0,
  "sobrevida": 98.3
}

Case 2

reference-002

Inputs

Age: < 50
Congestive heart failure: Yes
Chronic pulmonary disease: Yes
Liver disease: No
Diabetes mellitus: No
Solid tumor: No
Previous myocardial infarction: No
Peripheral arterial disease (or aortic aneurysm ≥ 6 cm): No
Cerebrovascular disease (stroke with mild residual deficit or TIA): No
Dementia: No
Connective tissue disease (SLE, polymyositis, rheumatoid arthritis, polymyalgia): No
Peptic ulcer disease: No
Hemiplegia: No
Moderate or severe renal disease (creatinine > 3 mg/dL, dialysis or transplant): No
Leukemia: No
Lymphoma: No
AIDS (not HIV positivity alone): No

{
  "idade": "0",
  "icc": true,
  "dpoc": true,
  "figado": "0",
  "dm": "0",
  "tumor": "0",
  "iam": false,
  "dap": false,
  "avc": false,
  "demencia": false,
  "colageno": false,
  "ulcera": false,
  "hemiplegia": false,
  "renal": false,
  "leucemia": false,
  "linfoma": false,
  "aids": false
}

Expected result

{
  "sobrevida": 90.15
}

Actual result

{
  "score": 2,
  "cci": 2,
  "sobrevida": 90.14702690368213
}

Case 3

reference-003

Inputs

Age: 60 to 69
Previous myocardial infarction: Yes
Liver disease: No
Diabetes mellitus: No target-organ damage
Solid tumor: No
Congestive heart failure: No
Peripheral arterial disease (or aortic aneurysm ≥ 6 cm): No
Cerebrovascular disease (stroke with mild residual deficit or TIA): No
Dementia: No
Chronic pulmonary disease: No
Connective tissue disease (SLE, polymyositis, rheumatoid arthritis, polymyalgia): No
Peptic ulcer disease: No
Hemiplegia: No
Moderate or severe renal disease (creatinine > 3 mg/dL, dialysis or transplant): No
Leukemia: No
Lymphoma: No
AIDS (not HIV positivity alone): No

{
  "idade": "2",
  "iam": true,
  "figado": "0",
  "dm": "1",
  "tumor": "0",
  "icc": false,
  "dap": false,
  "avc": false,
  "demencia": false,
  "dpoc": false,
  "colageno": false,
  "ulcera": false,
  "hemiplegia": false,
  "renal": false,
  "leucemia": false,
  "linfoma": false,
  "aids": false
}

Expected result

{
  "cci": 2,
  "sobrevida": 53.39
}

Actual result

{
  "score": 4,
  "cci": 2,
  "sobrevida": 53.39147265666947
}

Case 4

reference-004

Inputs

Age: 70 to 79
Liver disease: No
Diabetes mellitus: No
Solid tumor: Metastatic
Previous myocardial infarction: No
Congestive heart failure: No
Peripheral arterial disease (or aortic aneurysm ≥ 6 cm): No
Cerebrovascular disease (stroke with mild residual deficit or TIA): No
Dementia: No
Chronic pulmonary disease: No
Connective tissue disease (SLE, polymyositis, rheumatoid arthritis, polymyalgia): No
Peptic ulcer disease: No
Hemiplegia: No
Moderate or severe renal disease (creatinine > 3 mg/dL, dialysis or transplant): No
Leukemia: No
Lymphoma: No
AIDS (not HIV positivity alone): No

{
  "idade": "3",
  "figado": "0",
  "dm": "0",
  "tumor": "6",
  "iam": false,
  "icc": false,
  "dap": false,
  "avc": false,
  "demencia": false,
  "dpoc": false,
  "colageno": false,
  "ulcera": false,
  "hemiplegia": false,
  "renal": false,
  "leucemia": false,
  "linfoma": false,
  "aids": false
}

Expected result

{
  "cci": 6,
  "sobrevida": 0
}

Actual result

{
  "score": 9,
  "cci": 6,
  "sobrevida": 2.936312167835233e-23
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

Support for research — context required

A general comorbidity index. It may support characterization or adjustment of oncology cohorts, with a defined version and methodological purpose.

Applications: Clinical trials and methods · Survival and quality of life