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Anaphylaxis severity (Brown)

Classifies generalized hypersensitivity reaction severity by the most severe finding, following Brown (2004).

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

Brown 2004: 3 grades, most severe finding; SpO₂≤92/SBP<90/neurological

The Brown classification was studied retrospectively in systemic hypersensitivity reactions in emergency care. Severity is not a complete diagnostic definition or a standalone treatment rule. Numerical thresholds and definitions for the version must be checked in the full method; signs and application conditions cannot be replaced by the total alone.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Skin and subcutaneous tissue: generalized erythema, urticaria, periorbital edema or angioedema
Respiratory: dyspnea, stridor, wheezing, chest or throat tightness
Gastrointestinal: nausea, vomiting, abdominal pain
Presyncope (dizziness) or sweating
Hypoxemia (SpO₂ ≤ 92%) or cyanosis
Hypotension (systolic blood pressure < 90 mmHg in adults)
Neurological impairment: confusion, collapse, loss of consciousness or incontinence

5/5 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

Grade is defined by the most severe finding:

Grade 1 (mild): skin and subcutaneous tissue only.
Grade 2 (moderate): respiratory, cardiovascular or gastrointestinal involvement.
Grade 3 (severe): hypoxemia (SpO₂ ≤ 92% or cyanosis), hypotension (SBP < 90 mmHg) or neurological impairment.

References

Identifier: gravidade-da-anafilaxia

Original clinical content: Brazilian Portuguese.

Method version

Brown 2004: 3 grades, most severe finding; SpO₂≤92/SBP<90/neurological

gravidade-da-anafilaxia@native-2026-10-03+eb5f0efba0c6

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (5)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Skin and subcutaneous tissue: generalized erythema, urticaria, periorbital edema or angioedema: Yes
Respiratory: dyspnea, stridor, wheezing, chest or throat tightness: No
Gastrointestinal: nausea, vomiting, abdominal pain: No
Presyncope (dizziness) or sweating: No
Hypoxemia (SpO₂ ≤ 92%) or cyanosis: No
Hypotension (systolic blood pressure < 90 mmHg in adults): No
Neurological impairment: confusion, collapse, loss of consciousness or incontinence: No

{
  "pele": true,
  "resp": false,
  "gi": false,
  "cardio": false,
  "hipoxia": false,
  "hipotensao": false,
  "neuro": false
}

Expected result

{
  "grau": 1
}

Actual result

{
  "grau": 1
}

Case 2

reference-002

Inputs

Skin and subcutaneous tissue: generalized erythema, urticaria, periorbital edema or angioedema: Yes
Respiratory: dyspnea, stridor, wheezing, chest or throat tightness: Yes
Gastrointestinal: nausea, vomiting, abdominal pain: No
Presyncope (dizziness) or sweating: No
Hypoxemia (SpO₂ ≤ 92%) or cyanosis: No
Hypotension (systolic blood pressure < 90 mmHg in adults): No
Neurological impairment: confusion, collapse, loss of consciousness or incontinence: No

{
  "pele": true,
  "resp": true,
  "gi": false,
  "cardio": false,
  "hipoxia": false,
  "hipotensao": false,
  "neuro": false
}

Expected result

{
  "grau": 2
}

Actual result

{
  "grau": 2
}

Case 3

reference-003

Inputs

Gastrointestinal: nausea, vomiting, abdominal pain: Yes
Skin and subcutaneous tissue: generalized erythema, urticaria, periorbital edema or angioedema: No
Respiratory: dyspnea, stridor, wheezing, chest or throat tightness: No
Presyncope (dizziness) or sweating: No
Hypoxemia (SpO₂ ≤ 92%) or cyanosis: No
Hypotension (systolic blood pressure < 90 mmHg in adults): No
Neurological impairment: confusion, collapse, loss of consciousness or incontinence: No

{
  "gi": true,
  "pele": false,
  "resp": false,
  "cardio": false,
  "hipoxia": false,
  "hipotensao": false,
  "neuro": false
}

Expected result

{
  "grau": 2
}

Actual result

{
  "grau": 2
}

Case 4

reference-004

Inputs

Skin and subcutaneous tissue: generalized erythema, urticaria, periorbital edema or angioedema: Yes
Respiratory: dyspnea, stridor, wheezing, chest or throat tightness: Yes
Hypotension (systolic blood pressure < 90 mmHg in adults): Yes
Gastrointestinal: nausea, vomiting, abdominal pain: No
Presyncope (dizziness) or sweating: No
Hypoxemia (SpO₂ ≤ 92%) or cyanosis: No
Neurological impairment: confusion, collapse, loss of consciousness or incontinence: No

{
  "pele": true,
  "resp": true,
  "hipotensao": true,
  "gi": false,
  "cardio": false,
  "hipoxia": false,
  "neuro": false
}

Expected result

{
  "grau": 3
}

Actual result

{
  "grau": 3
}

Case 5

reference-005

Inputs

Skin and subcutaneous tissue: generalized erythema, urticaria, periorbital edema or angioedema: No
Respiratory: dyspnea, stridor, wheezing, chest or throat tightness: No
Gastrointestinal: nausea, vomiting, abdominal pain: No
Presyncope (dizziness) or sweating: No
Hypoxemia (SpO₂ ≤ 92%) or cyanosis: No
Hypotension (systolic blood pressure < 90 mmHg in adults): No
Neurological impairment: confusion, collapse, loss of consciousness or incontinence: No

{
  "pele": false,
  "resp": false,
  "gi": false,
  "cardio": false,
  "hipoxia": false,
  "hipotensao": false,
  "neuro": false
}

Expected result

{
  "error": true
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

General context — relationship to be defined

A resource for general clinical contexts. This edition does not assign a specific oncological relationship; selecting it for a study requires a justified question, population and purpose.