PUBLIC LIBRARY / CALCULATOR

Gleason and ISUP Grade Group

Maps prostate adenocarcinoma Gleason score to ISUP Grade Group (1 to 5), improving prognostic separation, especially 3 + 4 versus 4 + 3.

Calculate with transparency

Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

ISUP consensus 2014/publication 2016: 5 groups, 3+4/4+3 distinction

Conversion into ISUP grade groups assumes correctly assigned Gleason patterns in prostate cancer histology; 3+4 is not equivalent to 4+3. The 2014 consensus does not recommend Gleason grading of intraductal carcinoma without invasive carcinoma. The calculator does not determine the patterns or replace pathological assessment.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Primary pattern (most extensive)
Secondary pattern

5/5 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

Gleason ≤ 6 = group 1 · 3 + 4 = 7 = group 2 · 4 + 3 = 7 = group 3 · 8 (4 + 4, 3 + 5, 5 + 3) = group 4 · 9–10 = group 5.

References

Identifier: gleason-isup

Original clinical content: Brazilian Portuguese.

Method version

ISUP consensus 2014/publication 2016: 5 groups, 3+4/4+3 distinction

gleason-isup@native-2026-10-03+3702311f064a

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (5)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Primary pattern (most extensive): 3
Secondary pattern: 3

{
  "p": "3",
  "s": "3"
}

Expected result

{
  "gg": 1,
  "sum": 6
}

Actual result

{
  "gg": 1,
  "sum": 6
}

Case 2

reference-002

Inputs

Primary pattern (most extensive): 3
Secondary pattern: 4

{
  "p": "3",
  "s": "4"
}

Expected result

{
  "gg": 2
}

Actual result

{
  "gg": 2,
  "sum": 7
}

Case 3

reference-003

Inputs

Primary pattern (most extensive): 4
Secondary pattern: 3

{
  "p": "4",
  "s": "3"
}

Expected result

{
  "gg": 3
}

Actual result

{
  "gg": 3,
  "sum": 7
}

Case 4

reference-004

Inputs

Primary pattern (most extensive): 3
Secondary pattern: 5

{
  "p": "3",
  "s": "5"
}

Expected result

{
  "gg": 4
}

Actual result

{
  "gg": 4,
  "sum": 8
}

Case 5

reference-005

Inputs

Primary pattern (most extensive): 5
Secondary pattern: 4

{
  "p": "5",
  "s": "4"
}

Expected result

{
  "gg": 5,
  "sum": 9
}

Actual result

{
  "gg": 5,
  "sum": 9
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

Specific oncological application

Histological grouping of prostate carcinoma. It depends on a pathology report and does not diagnose from clinical data.

Applications: Biomarkers