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MACIS (papillary thyroid carcinoma)

Estimates 20-year cancer-specific survival in papillary thyroid carcinoma from five postoperative data points.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

MACIS/Hay 1993: age/size/resection/invasion/metastasis; 3.1 up to age 39 versus 0.08×age ≥40

Prognosis of papillary thyroid carcinoma from data available after the primary operation, including completeness of resection and size in cm. Do not automatically extrapolate to another histology or preoperative use without resection information. Calibration belongs to the historical cohorts studied.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Age at diagnosis · years
Largest tumor diameter · cm
Incomplete resection?
Local invasion (extrathyroidal)?
Distant metastasis?

4/4 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

MACIS = 3.1 (if age ≤ 39 years) or 0.08 × age (if age ≥ 40 years) + 0.3 × tumor size (cm) + 1 (incomplete resection) + 1 (local invasion) + 3 (distant metastasis).

References

Hay ID et al. Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. Surgery, 1993.

Identifier: escore-macis

Original clinical content: Brazilian Portuguese.

Method version

MACIS/Hay 1993: age/size/resection/invasion/metastasis; 3.1 up to age 39 versus 0.08×age ≥40

escore-macis@native-2026-10-03+396e9208d664

Hay ID et al. Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort of 1779 patients surgically treated at one institution during 1940 through 1989. Surgery, 1993.

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (4)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Age at diagnosis: 35 years
Largest tumor diameter: 2 cm
Incomplete resection?: No
Local invasion (extrathyroidal)?: No
Distant metastasis?: No

{
  "idade": 35,
  "tamanho": 2,
  "incompleta": "0",
  "invasao": "0",
  "metastase": "0"
}

Expected result

{
  "score": 3.7,
  "sobrevida": 99
}

Actual result

{
  "score": 3.7,
  "sobrevida": 99
}

Case 2

reference-002

Inputs

Age at diagnosis: 55 years
Largest tumor diameter: 5 cm
Incomplete resection?: Yes
Local invasion (extrathyroidal)?: No
Distant metastasis?: No

{
  "idade": 55,
  "tamanho": 5,
  "incompleta": "1",
  "invasao": "0",
  "metastase": "0"
}

Expected result

{
  "score": 6.9,
  "sobrevida": 89
}

Actual result

{
  "score": 6.9,
  "sobrevida": 89
}

Case 3

reference-003

Inputs

Age at diagnosis: 60 years
Largest tumor diameter: 4 cm
Incomplete resection?: No
Local invasion (extrathyroidal)?: Yes
Distant metastasis?: No

{
  "idade": 60,
  "tamanho": 4,
  "incompleta": "0",
  "invasao": "1",
  "metastase": "0"
}

Expected result

{
  "score": 7,
  "sobrevida": 56
}

Actual result

{
  "score": 7,
  "sobrevida": 56
}

Case 4

reference-004

Inputs

Age at diagnosis: 70 years
Largest tumor diameter: 5 cm
Incomplete resection?: No
Local invasion (extrathyroidal)?: No
Distant metastasis?: Yes

{
  "idade": 70,
  "tamanho": 5,
  "incompleta": "0",
  "invasao": "0",
  "metastase": "1"
}

Expected result

{
  "score": 10.1,
  "sobrevida": 24
}

Actual result

{
  "score": 10.1,
  "sobrevida": 24
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

Specific oncological application

A prognostic model for papillary thyroid carcinoma. Applicability depends on the population and context of the source.

Applications: Survival and quality of life