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Driving pressure and static compliance

Driving pressure is pressure change during the respiratory cycle, reflecting tidal volume relative to aerated lung; it was the ventilation variable most associated with ARDS survival.

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Method · Limits of application

ΔP=Pplat−PEEP; Cstat=VT/ΔP; Amato 2015 passive-ventilation context

Amato’s 2015 analysis studied 3562 patients with ARDS from nine previous trials, in the context of ventilation without active breathing. Driving pressure was analyzed as VT/CRS and as a variable associated with survival; that association alone does not establish a universal threshold or a therapeutic intervention guided by the calculation. Measurement technique and ventilatory conditions must be checked.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Tidal volume · mL
Plateau pressure (inspiratory pause) · cmH₂O
Total PEEP · cmH₂O
Predicted body weight · kg

4/4 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

Driving pressure (ΔP) = plateau pressure − PEEP.

Static compliance = tidal volume ÷ ΔP (mL/cmH₂O).

References

Identifier: driving-pressure

Original clinical content: Brazilian Portuguese.

Method version

ΔP=Pplat−PEEP; Cstat=VT/ΔP; Amato 2015 passive-ventilation context

driving-pressure@native-2026-10-05+9858e74ae512

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (4)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Tidal volume: 420 mL
Plateau pressure (inspiratory pause): 25 cmH₂O
Total PEEP: 10 cmH₂O

{
  "vt": 420,
  "pplat": 25,
  "peep": 10
}

Expected result

{
  "dp": 15,
  "cst": 28
}

Actual result

{
  "dp": 15,
  "cst": 28
}

Case 2

reference-002

Inputs

Tidal volume: 450 mL
Plateau pressure (inspiratory pause): 30 cmH₂O
Total PEEP: 8 cmH₂O

{
  "vt": 450,
  "pplat": 30,
  "peep": 8
}

Expected result

{
  "dp": 22,
  "cst": 20.45
}

Actual result

{
  "dp": 22,
  "cst": 20.454545454545453
}

Case 3

reference-003

Inputs

Tidal volume: 500 mL
Plateau pressure (inspiratory pause): 18 cmH₂O
Total PEEP: 5 cmH₂O
Predicted body weight: 70 kg

{
  "vt": 500,
  "pplat": 18,
  "peep": 5,
  "pbw": 70
}

Expected result

{
  "dp": 13,
  "cst": 38.46
}

Actual result

{
  "dp": 13,
  "cst": 38.46153846153846
}

Case 4

reference-004

Inputs

Tidal volume: 400 mL
Plateau pressure (inspiratory pause): 6 cmH₂O
Total PEEP: 8 cmH₂O

{
  "vt": 400,
  "pplat": 6,
  "peep": 8
}

Expected result

{
  "error": true
}

Code and reproducibility

This tool’s code on GitHub

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Sources, version and reproduction instructions

README

Local installation

Code license: Apache-2.0

Guidelines and conditions

This repository’s license applies to the code. Third-party instruments, questionnaires, data and models remain subject to their owners’ conditions.

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

General context — relationship to be defined

A resource for general clinical contexts. This edition does not assign a specific oncological relationship; selecting it for a study requires a justified question, population and purpose.