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Carboplatin dose (Calvert)

Calculates AUC × (measured GFR + 25), using the protocol-defined AUC and measured GFR in mL/min. This edition does not replace measured GFR with Cockcroft–Gault or apply a universal 125 mL/min cap.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

Calvert 1989; mGFR without a universal cap; ADDIKD 2022

This implementation uses measured GFR exclusively. It does not substitute Cockcroft–Gault for GFR, convert an indexed estimate without body surface area, or select the AUC, protocol or reduction.

Conditions of use

Check the conditions of application before calculating. The result presents the documented formula or criteria; it does not establish a diagnosis or prescription.

Scope of this implementation

This implementation uses measured GFR exclusively. It does not substitute Cockcroft–Gault for GFR, convert an indexed estimate without body surface area, or select the AUC, protocol or reduction.

Parameters in this edition

Prescribed target AUC · mg/mL·min
Measured non-indexed GFR · mL/min
Age · years
GFR measured using an exogenous marker, in non-indexed mL/min, and protocol AUC confirmed?

Sources and documentation

Method version

Calvert 1989; mGFR without a universal cap; ADDIKD 2022

Formula and criteria

Calvert formula dose (mg) = target AUC × (measured GFR in mL/min + 25). No universal 125 mL/min cap is applied.

Population and limitations

This implementation uses measured GFR exclusively. It does not substitute Cockcroft–Gault for GFR, convert an indexed estimate without body surface area, or select the AUC, protocol or reduction.

Synthetic cases checked (3)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Prescribed target AUC: 5 mg/mL·min
Measured non-indexed GFR: 135 mL/min
Age: 60 years
GFR measured using an exogenous marker, in non-indexed mL/min, and protocol AUC confirmed?: Yes

{
  "auc": 5,
  "tfg": 135,
  "idade": 60,
  "contexto": "1"
}

Expected result

{
  "dose": 800,
  "gfr": 135,
  "auc": 5
}

Actual result

{
  "dose": 800,
  "gfr": 135,
  "auc": 5
}

Case 2

reference-002

Inputs

Prescribed target AUC: 5 mg/mL·min
Measured non-indexed GFR: 100 mL/min
Age: 60 years
GFR measured using an exogenous marker, in non-indexed mL/min, and protocol AUC confirmed?: Yes

{
  "auc": 5,
  "tfg": 100,
  "idade": 60,
  "contexto": "1"
}

Expected result

{
  "dose": 625,
  "gfr": 100
}

Actual result

{
  "dose": 625,
  "gfr": 100,
  "auc": 5
}

Case 3

reference-003

Inputs

Prescribed target AUC: 5 mg/mL·min
Measured non-indexed GFR: 250 mL/min
Age: 60 years
GFR measured using an exogenous marker, in non-indexed mL/min, and protocol AUC confirmed?: Yes

{
  "auc": 5,
  "tfg": 250,
  "idade": 60,
  "contexto": "1"
}

Expected result

{
  "dose": 1375,
  "gfr": 250
}

Actual result

{
  "dose": 1375,
  "gfr": 250,
  "auc": 5
}

Source for the active edition

eviQ · Carboplatin Dose Calculator · v1 / ADDIKD 2022

Additional reading and history

Identifier: dose-de-carboplatina

Original clinical content: Brazilian Portuguese.

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

Specific oncological application

The Calvert formula for studying and checking carboplatin dosing. Defining target exposure and the renal measurement requires a protocol and professional judgment.

Applications: Pharmacology · Adverse effects and safety