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2023 Duke–ISCVID criteria

Classifies suspected infective endocarditis as definite, possible or rejected by combining pathological, major and minor criteria.

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Method · Limits of application

Duke-ISCVID 2023: selected Table 1 combinations; the surgical major criterion is subject to Table 2, I.C, requiring the absence of a major imaging criterion and of subsequent confirmation; no automatic equivalence with Duke 2000

The Duke-ISCVID 2023 criteria depend on specific definitions for microbiology, imaging, intraoperative inspection and predisposing conditions. Some microorganisms are classified as typical only in the presence of an intracardiac prosthesis. The 2023 edition also changes culture requirements from the previous edition; counts alone without these definitions do not reproduce the complete system. Table 2, section I.C, restricts the surgical major criterion to the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation. In this interface, selecting the pathological criterion prevents an additional surgical major count; the blood microbiological major criterion remains separate. The person completing the form must check subsequent confirmation and the source definitions: the Boolean fields do not record the entire chronology or how findings were established. This check corrects only this count and its selected combinations; it does not validate diagnosis, clinical performance, treatment or the complete method.

Required fields: 0/14 completed

Complete all required fields. Optional fields are marked.

Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology required

Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800) required

Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead required

Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation required

Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use) required

Minor: fever > 38.0 °C required

Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura) required

Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis) required

Minor: microbiological evidence that does not meet a major criterion required

Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation required

Minor: new regurgitant murmur on physical examination if echocardiography is unavailable required

Rejected: a firm alternative diagnosis explains the presentation required

Rejected: no recurrence after fewer than 4 days of antibiotic therapy required

Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy required

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Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology
Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800)
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation
Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use)
Minor: fever > 38.0 °C
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura)
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis)
Minor: microbiological evidence that does not meet a major criterion
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable
Rejected: a firm alternative diagnosis explains the presentation
Rejected: no recurrence after fewer than 4 days of antibiotic therapy
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy

8/8 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

Definite: pathological criterion, or 2 major, or 1 major + 3 minor, or 5 minor.
Possible: 1 major + 1 minor, or 3 minor.
Rejected: firm alternative diagnosis, resolution without recurrence after less than 4 days of antibiotics, no pathological evidence at surgery/autopsy after less than 4 days of antibiotics, or does not meet possible criteria.

Surgical major count: adds one major criterion only when selected and neither a major imaging criterion nor the pathological criterion is selected. The subsequent confirmation described in Table 2 must be checked; a blood microbiological major criterion is not automatically subsequent tissue confirmation.

References

Identifier: criterios-de-duke

Original clinical content: Brazilian Portuguese.

Method version

criterios-de-duke@duke2023-surgical-source-2026-10-04+0be5980821b1

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (8)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): Yes
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: Yes
Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): No
Minor: fever > 38.0 °C: No
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): No
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): No
Minor: microbiological evidence that does not meet a major criterion: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: a firm alternative diagnosis explains the presentation: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "maior_micro": true,
  "maior_img": true,
  "pato": false,
  "maior_cir": false,
  "men_pred": false,
  "men_febre": false,
  "men_vasc": false,
  "men_imuno": false,
  "men_micro": false,
  "men_img": false,
  "men_exame": false,
  "rej_alt": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "maiores": 2,
  "menores": 0,
  "cls": "definida"
}

Actual result

{
  "maiores": 2,
  "menores": 0,
  "cls": "definida"
}

Case 2

reference-002

Inputs

Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): Yes
Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): Yes
Minor: fever > 38.0 °C: Yes
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): Yes
Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: No
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): No
Minor: microbiological evidence that does not meet a major criterion: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: a firm alternative diagnosis explains the presentation: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "maior_micro": true,
  "men_pred": true,
  "men_febre": true,
  "men_vasc": true,
  "pato": false,
  "maior_img": false,
  "maior_cir": false,
  "men_imuno": false,
  "men_micro": false,
  "men_img": false,
  "men_exame": false,
  "rej_alt": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "cls": "definida"
}

Actual result

{
  "maiores": 1,
  "menores": 3,
  "cls": "definida"
}

Case 3

reference-003

Inputs

Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): Yes
Minor: fever > 38.0 °C: Yes
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): Yes
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): Yes
Minor: microbiological evidence that does not meet a major criterion: Yes
Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: No
Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): No
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: a firm alternative diagnosis explains the presentation: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "men_pred": true,
  "men_febre": true,
  "men_vasc": true,
  "men_imuno": true,
  "men_micro": true,
  "pato": false,
  "maior_micro": false,
  "maior_img": false,
  "maior_cir": false,
  "men_img": false,
  "men_exame": false,
  "rej_alt": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "menores": 5,
  "cls": "definida"
}

Actual result

{
  "maiores": 0,
  "menores": 5,
  "cls": "definida"
}

Case 4

reference-004

Inputs

Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: Yes
Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): No
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): No
Minor: fever > 38.0 °C: No
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): No
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): No
Minor: microbiological evidence that does not meet a major criterion: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: a firm alternative diagnosis explains the presentation: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "pato": true,
  "maior_micro": false,
  "maior_img": false,
  "maior_cir": false,
  "men_pred": false,
  "men_febre": false,
  "men_vasc": false,
  "men_imuno": false,
  "men_micro": false,
  "men_img": false,
  "men_exame": false,
  "rej_alt": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "cls": "definida"
}

Actual result

{
  "maiores": 0,
  "menores": 0,
  "cls": "definida"
}

Case 5

reference-005

Inputs

Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: Yes
Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): Yes
Minor: fever > 38.0 °C: Yes
Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: No
Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): No
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): No
Minor: microbiological evidence that does not meet a major criterion: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: a firm alternative diagnosis explains the presentation: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "maior_img": true,
  "men_pred": true,
  "men_febre": true,
  "pato": false,
  "maior_micro": false,
  "maior_cir": false,
  "men_vasc": false,
  "men_imuno": false,
  "men_micro": false,
  "men_img": false,
  "men_exame": false,
  "rej_alt": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "cls": "possível"
}

Actual result

{
  "maiores": 1,
  "menores": 2,
  "cls": "possível"
}

Case 6

reference-006

Inputs

Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): Yes
Minor: fever > 38.0 °C: Yes
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): Yes
Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: No
Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): No
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): No
Minor: microbiological evidence that does not meet a major criterion: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: a firm alternative diagnosis explains the presentation: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "men_pred": true,
  "men_febre": true,
  "men_imuno": true,
  "pato": false,
  "maior_micro": false,
  "maior_img": false,
  "maior_cir": false,
  "men_vasc": false,
  "men_micro": false,
  "men_img": false,
  "men_exame": false,
  "rej_alt": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "cls": "possível"
}

Actual result

{
  "maiores": 0,
  "menores": 3,
  "cls": "possível"
}

Case 7

reference-007

Inputs

Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): Yes
Minor: fever > 38.0 °C: Yes
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): Yes
Rejected: a firm alternative diagnosis explains the presentation: Yes
Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: No
Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): No
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): No
Minor: microbiological evidence that does not meet a major criterion: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "men_pred": true,
  "men_febre": true,
  "men_imuno": true,
  "rej_alt": true,
  "pato": false,
  "maior_micro": false,
  "maior_img": false,
  "maior_cir": false,
  "men_vasc": false,
  "men_micro": false,
  "men_img": false,
  "men_exame": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "cls": "rejeitada"
}

Actual result

{
  "maiores": 0,
  "menores": 3,
  "cls": "rejeitada"
}

Case 8

reference-008

Inputs

Minor: predisposition (previous endocarditis, prosthetic valve, valve repair, congenital heart disease, valve regurgitation or stenosis, intracardiac device, hypertrophic cardiomyopathy, injection drug use): Yes
Minor: fever > 38.0 °C: Yes
Pathological criterion: microorganism in vegetation, cardiac tissue, prosthesis or embolus (culture, histology or PCR), or active endocarditis on histology: No
Major microbiological criterion: typical organism in ≥ 2 separate blood cultures, occasional organism in ≥ 3, blood PCR positive for Coxiella, Bartonella or T. whipplei, or specific serology (phase I IgG against C. burnetii > 1:800; IgG against Bartonella ≥ 1:800): No
Major imaging criterion: vegetation, perforation, aneurysm, abscess, pseudoaneurysm or fistula on echocardiography/cardiac CT; significant new valvular regurgitation; new prosthetic dehiscence; or abnormal FDG uptake on PET/CT in a valve or lead: No
Surgical major criterion: endocarditis documented by direct inspection during cardiac surgery, only in the absence of a major imaging criterion and subsequent histologic or microbiologic confirmation: No
Minor: vascular phenomena (arterial embolism, septic pulmonary infarction, cerebral or splenic abscess, mycotic aneurysm, intracranial hemorrhage, conjunctival hemorrhage, Janeway lesions, purulent purpura): No
Minor: immunological phenomena (positive rheumatoid factor, Osler nodes, Roth spots, immune-complex glomerulonephritis): No
Minor: microbiological evidence that does not meet a major criterion: No
Minor: abnormal FDG PET/CT within 3 months of prosthesis, graft or device implantation: No
Minor: new regurgitant murmur on physical examination if echocardiography is unavailable: No
Rejected: a firm alternative diagnosis explains the presentation: No
Rejected: no recurrence after fewer than 4 days of antibiotic therapy: No
Rejected: no pathological evidence at surgery or autopsy, with fewer than 4 days of antibiotic therapy: No

{
  "men_pred": true,
  "men_febre": true,
  "pato": false,
  "maior_micro": false,
  "maior_img": false,
  "maior_cir": false,
  "men_vasc": false,
  "men_imuno": false,
  "men_micro": false,
  "men_img": false,
  "men_exame": false,
  "rej_alt": false,
  "rej_res": false,
  "rej_pato": false
}

Expected result

{
  "cls": "rejeitada"
}

Actual result

{
  "maiores": 0,
  "menores": 2,
  "cls": "rejeitada"
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

General context — relationship to be defined

A resource for general clinical contexts. This edition does not assign a specific oncological relationship; selecting it for a study requires a justified question, population and purpose.