PUBLIC LIBRARY / CALCULATOR

Creatinine clearance from 24-hour urine

Measures creatinine clearance from 24-hour urine and serum creatinine, useful when estimated GFR is unreliable, including muscle-mass extremes, amputations or special diets.

Calculate with transparency

Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

Preparing the form…

Check the method
Enter the data
Check the result

Method · Limits of application

24 h urinary clearance: UCr×volume/(PCr×1440); indexing 1.73/Mosteller BSA

This calculation requires a complete 24-hour urine collection and urinary and serum creatinine in compatible units. The volume is converted to mL/min by dividing by 1440 minutes. Incomplete or excessive collection can distort the result; KDIGO 2024 highlights these errors. Creatinine clearance is not a direct measurement of glomerular filtration rate. The absolute value in mL/min differs from the optional value indexed to 1.73 m²; enter height and weight for this indexing and check which unit the protocol requires.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Urine creatinine · mg/dL
24-hour urine volume · mL
Serum creatinine · mg/dL
Sex
Weight (for correction and collection check) · kg
Height (for correction to 1.73 m²) · cm

3/3 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

ClCr (mL/min) = (urinary creatinine × 24 h volume in mL) ÷ (serum creatinine × 1440).

Corrected = ClCr × 1.73 ÷ body surface area (Mosteller). Excreted creatinine (mg/kg/day) = urinary creatinine × volume (dL) ÷ weight.

References

Identifier: clearance-de-creatinina-urina-24h

Original clinical content: Brazilian Portuguese.

Method version

24 h urinary clearance: UCr×volume/(PCr×1440); indexing 1.73/Mosteller BSA

clearance-de-creatinina-urina-24h@native-2026-10-03+f5e6a12acf90

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (3)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Urine creatinine: 100 mg/dL
24-hour urine volume: 1,440 mL
Serum creatinine: 1 mg/dL
Sex: Male
Weight (for correction and collection check): 70 kg
Height (for correction to 1.73 m²): 170 cm

{
  "ucr": 100,
  "vol": 1440,
  "pcr": 1,
  "sexo": "M",
  "peso": 70,
  "altura": 170
}

Expected result

{
  "cl": 100,
  "clc": 95.153,
  "exc": 20.571
}

Actual result

{
  "cl": 100,
  "clc": 95.15330399152833,
  "exc": 20.571428571428573
}

Case 2

reference-002

Inputs

Urine creatinine: 80 mg/dL
24-hour urine volume: 1,500 mL
Serum creatinine: 1.5 mg/dL
Sex: Female

{
  "ucr": 80,
  "vol": 1500,
  "pcr": 1.5,
  "sexo": "F"
}

Expected result

{
  "cl": 55.556
}

Actual result

{
  "cl": 55.55555555555556,
  "clc": null,
  "exc": null
}

Case 3

reference-003

Inputs

Urine creatinine: 60 mg/dL
24-hour urine volume: 1,000 mL
Serum creatinine: 2 mg/dL
Sex: Male

{
  "ucr": 60,
  "vol": 1000,
  "pcr": 2,
  "sexo": "M"
}

Expected result

{
  "cl": 20.833
}

Actual result

{
  "cl": 20.833333333333332,
  "clc": null,
  "exc": null
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

Support for research — context required

A clearance measurement dependent on urine collection. It can form part of renal function or safety studies, with a specific protocol and collection quality control.

Applications: Pharmacology · Adverse effects and safety