PUBLIC LIBRARY / CALCULATOR

Creatinine clearance (Cockcroft–Gault)

Estimates creatinine clearance, the reference used in prescribing information for direct oral anticoagulant, antiarrhythmic and other drug dose adjustment.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

Cockcroft–Gault 1976: (140−age)×weight/(72×Cr); female factor 0.85; non-indexed CrCl

Historical estimate of creatinine clearance in mL/min without body-surface-area indexing; it is not equivalent to measured GFR or the indexed CKD-EPI value. The calculation uses exactly the weight entered and does not automatically select actual, ideal or adjusted body weight. Atypical body size or muscle mass and conditions that alter creatinine may impair the estimate. For medication dosing, check the specific medicine’s label and protocol, the kidney-function method used and the need for confirmation, particularly with a narrow therapeutic index. The result alone does not prescribe a dose.

Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Age · years
Weight · kg
Serum creatinine · mg/dL
Sex

3/3 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

ClCr (mL/min) = [(140 − age) × weight] ÷ (72 × creatinine) × 0.85 in women.

References

Identifier: clearance-de-creatinina

Original clinical content: Brazilian Portuguese.

Method version

Cockcroft–Gault 1976: (140−age)×weight/(72×Cr); female factor 0.85; non-indexed CrCl

clearance-de-creatinina@native-2026-10-05+964e7156d8ea

Source for the active edition

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (3)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Age: 70 years
Weight: 70 kg
Serum creatinine: 1 mg/dL
Sex: Male

{
  "idade": 70,
  "peso": 70,
  "cr": 1,
  "sexo": "M"
}

Expected result

{
  "cl": 68.06
}

Actual result

{
  "cl": 68.05555555555556
}

Case 2

reference-002

Inputs

Age: 70 years
Weight: 70 kg
Serum creatinine: 1 mg/dL
Sex: Female

{
  "idade": 70,
  "peso": 70,
  "cr": 1,
  "sexo": "F"
}

Expected result

{
  "cl": 57.85
}

Actual result

{
  "cl": 57.84722222222222
}

Case 3

reference-003

Inputs

Age: 80 years
Weight: 50 kg
Serum creatinine: 2 mg/dL
Sex: Female

{
  "idade": 80,
  "peso": 50,
  "cr": 2,
  "sexo": "F"
}

Expected result

{
  "cl": 17.71
}

Actual result

{
  "cl": 17.708333333333332
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

README

Local installation

Code license: Apache-2.0

Guidelines and conditions

This repository’s license applies to the code. Third-party instruments, questionnaires, data and models remain subject to their owners’ conditions.

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.

Relationship with cancer research

Support for research — context required

A renal estimate for clinical and dosing contexts. In oncology protocols, use only when the equation and units are accepted by the protocol.

Applications: Pharmacology · Adverse effects and safety