PUBLIC LIBRARY / CALCULATOR

PCE2013 · historical model

Reproduces the historical 2013 equation for first nonfatal myocardial infarction, coronary death or fatal/nonfatal stroke over ten years. It does not estimate heart failure, lifetime risk or treatment effects.

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Check the population, units and version. The result shows the formula or classification; it does not make an automatic treatment decision.

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Method · Limits of application

PCE2013 · published Appendix 4, Tables A/B coefficients; historical model

Population categories are the source’s two historical US categories; do not silently substitute other groups. Age: 40–79 years; total cholesterol: 130–320 mg/dL; HDL: 20–100 mg/dL; systolic pressure: 90–200 mmHg. The three laboratory/pressure limits are legacy official-estimator conventions. Answer history and confirmation fields explicitly; unknown answers or exclusions do not produce an estimate. ACC states that PCE-derived ten-year risk is no longer supported by current clinical policy/guidelines. This is a historical research candidate, not PREVENT, treatment advice or clinical validation. One published White-male example remains discrepant: the equation using published coefficients rounds to 5.4%, while the table prints 5.3%. Coefficients were not changed to hide the difference. Distribution permission has not been obtained; clinical/professional review has not been performed.

Required fields: 0/17 completed

Complete all required fields. Optional fields are marked.

Sex in the published equation required

Derivation population group required

Age requiredyears · range 40–79

Total cholesterol requiredmg/dL · range 130–320

HDL cholesterol requiredmg/dL · range 20–100

Systolic blood pressure requiredmmHg · range 90–200

Current antihypertensive treatment? required

Current smoking? required

Diabetes? required

Previous myocardial infarction? required

Previous stroke? required

Previous heart failure? required

Previous percutaneous coronary intervention? required

Previous coronary artery bypass surgery? required

Previous atrial fibrillation? required

Apparently healthy status at baseline assessment confirmed? required

Use of the historical model for research confirmed? required

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Conditions of use

Check the population, units, inclusion and exclusion criteria, and version in the original source. A result alone does not establish a diagnosis, discharge decision or prescription.

Documented parameters

Sex in the published equation
Derivation population group
Age · years
Total cholesterol · mg/dL
HDL cholesterol · mg/dL
Systolic blood pressure · mmHg
Current antihypertensive treatment?
Current smoking?
Diabetes?
Previous myocardial infarction?
Previous stroke?
Previous heart failure?
Previous percutaneous coronary intervention?
Previous coronary artery bypass surgery?
Previous atrial fibrillation?
Apparently healthy status at baseline assessment confirmed?
Use of the historical model for research confirmed?

20/20 reference cases checked. Numerical tests are not clinical validation.

Sources and documentation

Documented formula

Transcribed from the source or a recorded revision; this is not a clinical recommendation.

10-year probability = 1 − S₀^{exp(ΣβX − mean)}; percentage = 100 × probability. X uses natural logarithms and interactions from the published population/sex column. Published coefficient precision is retained; one-decimal presentation does not change the raw result.

References

Identifier: acc-cvd-risk

Original clinical content: Brazilian Portuguese.

Method version

PCE2013 · published Appendix 4, Tables A/B coefficients; historical model

ELUCENIA PCE2013 published-coefficient historical research implementation; adapter R8

The bibliographic edition identifies the source. By itself, it proves neither full conformity of the formula nor clinical approval.

Synthetic cases checked (20)

Synthetic cases for checking the implementation, with no patient data.

Case 1

reference-001

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic White person
Age: 55 years
Total cholesterol: 213 mg/dL
HDL cholesterol: 50 mg/dL
Systolic blood pressure: 120 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicWhite",
  "ageYears": 55,
  "totalCholesterolMgDl": 213,
  "hdlCholesterolMgDl": 50,
  "systolicBpMmHg": 120,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 2.052229820249467
}

Actual result

{
  "linearPredictor": -29.676672052893,
  "meanPredictorSum": -29.18,
  "baselineSurvival": 0.9665,
  "centeredPredictor": -0.4966720528930004,
  "relativeHazard": 0.6085525241297984,
  "survivalLog": -0.02073580673925355,
  "tenYearProbability": 0.020522298202495015,
  "tenYearPercent": 2.0522298202495017,
  "terms": [
    {
      "name": "age",
      "coefficient": -29.799,
      "feature": 4.007333185232471,
      "product": -119.41452158674241
    },
    {
      "name": "age2",
      "coefficient": 4.884,
      "feature": 16.058719257465423,
      "product": 78.43078485346113
    },
    {
      "name": "tc",
      "coefficient": 13.54,
      "feature": 5.3612921657094255,
      "product": 72.59189592370562
    },
    {
      "name": "ageTc",
      "coefficient": -3.114,
      "feature": 21.484484011374246,
      "product": -66.9026832114194
    },
    {
      "name": "hdl",
      "coefficient": -13.578,
      "feature": 3.912023005428146,
      "product": -53.11744836770336
    },
    {
      "name": "ageHdl",
      "coefficient": 3.149,
      "feature": 15.676779611045077,
      "product": 49.36617899518095
    },
    {
      "name": "sbpT",
      "coefficient": 2.019,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.957,
      "feature": 4.787491742782046,
      "product": 9.369121340624464
    },
    {
      "name": "smoke",
      "coefficient": 7.574,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.665,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.661,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 2

reference-002

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic White person
Age: 40 years
Total cholesterol: 130 mg/dL
HDL cholesterol: 100 mg/dL
Systolic blood pressure: 90 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicWhite",
  "ageYears": 40,
  "totalCholesterolMgDl": 130,
  "hdlCholesterolMgDl": 100,
  "systolicBpMmHg": 90,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 0.03709739617920835
}

Actual result

{
  "linearPredictor": -33.69997193998835,
  "meanPredictorSum": -29.18,
  "baselineSurvival": 0.9665,
  "centeredPredictor": -4.519971939988352,
  "relativeHazard": 0.010889329218972276,
  "survivalLog": -0.00037104278965500624,
  "tenYearProbability": 0.00037097396179208605,
  "tenYearPercent": 0.037097396179208604,
  "terms": [
    {
      "name": "age",
      "coefficient": -29.799,
      "feature": 3.6888794541139363,
      "product": -109.92491885314118
    },
    {
      "name": "age2",
      "coefficient": 4.884,
      "feature": 13.607831626983932,
      "product": 66.46064966618952
    },
    {
      "name": "tc",
      "coefficient": 13.54,
      "feature": 4.867534450455582,
      "product": 65.90641645916858
    },
    {
      "name": "ageTc",
      "coefficient": -3.114,
      "feature": 17.955747826477367,
      "product": -55.91419873165052
    },
    {
      "name": "hdl",
      "coefficient": -13.578,
      "feature": 4.605170185988092,
      "product": -62.529000785346305
    },
    {
      "name": "ageHdl",
      "coefficient": 3.149,
      "feature": 16.987917681789526,
      "product": 53.49495277995522
    },
    {
      "name": "sbpT",
      "coefficient": 2.019,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.957,
      "feature": 4.499809670330265,
      "product": 8.806127524836329
    },
    {
      "name": "smoke",
      "coefficient": 7.574,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.665,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.661,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 3

reference-003

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic White person
Age: 79 years
Total cholesterol: 320 mg/dL
HDL cholesterol: 20 mg/dL
Systolic blood pressure: 200 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicWhite",
  "ageYears": 79,
  "totalCholesterolMgDl": 320,
  "hdlCholesterolMgDl": 20,
  "systolicBpMmHg": 200,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 85.51261878486854
}

Actual result

{
  "linearPredictor": -25.142278849018528,
  "meanPredictorSum": -29.18,
  "baselineSurvival": 0.9665,
  "centeredPredictor": 4.037721150981472,
  "relativeHazard": 56.69699159186172,
  "survivalLog": -1.931892176483967,
  "tenYearProbability": 0.8551261878486882,
  "tenYearPercent": 85.51261878486882,
  "terms": [
    {
      "name": "age",
      "coefficient": -29.799,
      "feature": 4.3694478524670215,
      "product": -130.20517655566476
    },
    {
      "name": "age2",
      "coefficient": 4.884,
      "feature": 19.092074535428665,
      "product": 93.24569203103361
    },
    {
      "name": "tc",
      "coefficient": 13.54,
      "feature": 5.768320995793772,
      "product": 78.10306628304767
    },
    {
      "name": "ageTc",
      "coefficient": -3.114,
      "feature": 25.204377787411527,
      "product": -78.4864324299995
    },
    {
      "name": "hdl",
      "coefficient": -13.578,
      "feature": 2.995732273553991,
      "product": -40.67605281031609
    },
    {
      "name": "ageHdl",
      "coefficient": 3.149,
      "feature": 13.089695949246632,
      "product": 41.21945254417764
    },
    {
      "name": "sbpT",
      "coefficient": 2.019,
      "feature": 5.298317366548036,
      "product": 10.697302763060486
    },
    {
      "name": "sbpU",
      "coefficient": 1.957,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 7.574,
      "feature": 1,
      "product": 7.574
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.665,
      "feature": 4.3694478524670215,
      "product": -7.275130674357591
    },
    {
      "name": "diabetes",
      "coefficient": 0.661,
      "feature": 1,
      "product": 0.661
    }
  ]
}

Case 4

reference-004

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic White person
Age: 53.25 years
Total cholesterol: 197.5 mg/dL
HDL cholesterol: 42.5 mg/dL
Systolic blood pressure: 137.25 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicWhite",
  "ageYears": 53.25,
  "totalCholesterolMgDl": 197.5,
  "hdlCholesterolMgDl": 42.5,
  "systolicBpMmHg": 137.25,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 8.48219790671467
}

Actual result

{
  "linearPredictor": -28.223988350587522,
  "meanPredictorSum": -29.18,
  "baselineSurvival": 0.9665,
  "centeredPredictor": 0.9560116494124777,
  "relativeHazard": 2.6013008567211022,
  "survivalLog": -0.08863667423408561,
  "tenYearProbability": 0.08482197906714718,
  "tenYearPercent": 8.482197906714719,
  "terms": [
    {
      "name": "age",
      "coefficient": -29.799,
      "feature": 3.9749978045895347,
      "product": -118.45095957896355
    },
    {
      "name": "age2",
      "coefficient": 4.884,
      "feature": 15.800607546491621,
      "product": 77.17016725706509
    },
    {
      "name": "tc",
      "coefficient": 13.54,
      "feature": 5.285738584341177,
      "product": 71.56890043197953
    },
    {
      "name": "ageTc",
      "coefficient": -3.114,
      "feature": 21.01079926839037,
      "product": -65.42762892176762
    },
    {
      "name": "hdl",
      "coefficient": -13.578,
      "feature": 3.7495040759303713,
      "product": -50.910766342982576
    },
    {
      "name": "ageHdl",
      "coefficient": 3.149,
      "feature": 14.904270470122738,
      "product": 46.9335477104165
    },
    {
      "name": "sbpT",
      "coefficient": 2.019,
      "feature": 4.92180408038964,
      "product": 9.937122438306684
    },
    {
      "name": "sbpU",
      "coefficient": 1.957,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 7.574,
      "feature": 1,
      "product": 7.574
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.665,
      "feature": 3.9749978045895347,
      "product": -6.6183713446415755
    },
    {
      "name": "diabetes",
      "coefficient": 0.661,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 5

reference-005

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic White person
Age: 68 years
Total cholesterol: 245 mg/dL
HDL cholesterol: 36 mg/dL
Systolic blood pressure: 162 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicWhite",
  "ageYears": 68,
  "totalCholesterolMgDl": 245,
  "hdlCholesterolMgDl": 36,
  "systolicBpMmHg": 162,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 25.963017731680814
}

Actual result

{
  "linearPredictor": -27.002735421315645,
  "meanPredictorSum": -29.18,
  "baselineSurvival": 0.9665,
  "centeredPredictor": 2.1772645786843547,
  "relativeHazard": 8.822140950234154,
  "survivalLog": -0.3006054572398618,
  "tenYearProbability": 0.2596301773168104,
  "tenYearPercent": 25.963017731681038,
  "terms": [
    {
      "name": "age",
      "coefficient": -29.799,
      "feature": 4.219507705176107,
      "product": -125.73711010654281
    },
    {
      "name": "age2",
      "coefficient": 4.884,
      "feature": 17.804245274040536,
      "product": 86.95593391841399
    },
    {
      "name": "tc",
      "coefficient": 13.54,
      "feature": 5.501258210544727,
      "product": 74.48703617077561
    },
    {
      "name": "ageTc",
      "coefficient": -3.114,
      "feature": 23.2126014075568,
      "product": -72.28404078313187
    },
    {
      "name": "hdl",
      "coefficient": -13.578,
      "feature": 3.58351893845611,
      "product": -48.657020146357056
    },
    {
      "name": "ageHdl",
      "coefficient": 3.149,
      "feature": 15.120685772460059,
      "product": 47.61503949747672
    },
    {
      "name": "sbpT",
      "coefficient": 2.019,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.957,
      "feature": 5.087596335232384,
      "product": 9.956426028049775
    },
    {
      "name": "smoke",
      "coefficient": 7.574,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.665,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.661,
      "feature": 1,
      "product": 0.661
    }
  ]
}

Case 6

reference-006

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic White person
Age: 55 years
Total cholesterol: 213 mg/dL
HDL cholesterol: 50 mg/dL
Systolic blood pressure: 120 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicWhite",
  "ageYears": 55,
  "totalCholesterolMgDl": 213,
  "hdlCholesterolMgDl": 50,
  "systolicBpMmHg": 120,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 5.3844219979087145
}

Actual result

{
  "linearPredictor": 60.699546225197835,
  "meanPredictorSum": 61.18,
  "baselineSurvival": 0.9144,
  "centeredPredictor": -0.48045377480216445,
  "relativeHazard": 0.6185026671926364,
  "survivalLog": -0.05534805116071166,
  "tenYearProbability": 0.053844219979087116,
  "tenYearPercent": 5.384421997908712,
  "terms": [
    {
      "name": "age",
      "coefficient": 12.344,
      "feature": 4.007333185232471,
      "product": 49.466520838509624
    },
    {
      "name": "tc",
      "coefficient": 11.853,
      "feature": 5.3612921657094255,
      "product": 63.54739604015382
    },
    {
      "name": "ageTc",
      "coefficient": -2.664,
      "feature": 21.484484011374246,
      "product": -57.23466540630099
    },
    {
      "name": "hdl",
      "coefficient": -7.99,
      "feature": 3.912023005428146,
      "product": -31.257063813370888
    },
    {
      "name": "ageHdl",
      "coefficient": 1.769,
      "feature": 15.676779611045077,
      "product": 27.732223131938742
    },
    {
      "name": "sbpT",
      "coefficient": 1.797,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.764,
      "feature": 4.787491742782046,
      "product": 8.445135434267529
    },
    {
      "name": "smoke",
      "coefficient": 7.837,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.795,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.658,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 7

reference-007

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic White person
Age: 40 years
Total cholesterol: 130 mg/dL
HDL cholesterol: 100 mg/dL
Systolic blood pressure: 90 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicWhite",
  "ageYears": 40,
  "totalCholesterolMgDl": 130,
  "hdlCholesterolMgDl": 100,
  "systolicBpMmHg": 90,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 0.09083943571466681
}

Actual result

{
  "linearPredictor": 56.590282464600136,
  "meanPredictorSum": 61.18,
  "baselineSurvival": 0.9144,
  "centeredPredictor": -4.589717535399863,
  "relativeHazard": 0.010155726601517827,
  "survivalLog": -0.0009088071973341058,
  "tenYearProbability": 0.0009083943571466583,
  "tenYearPercent": 0.09083943571466582,
  "terms": [
    {
      "name": "age",
      "coefficient": 12.344,
      "feature": 3.6888794541139363,
      "product": 45.535527981582426
    },
    {
      "name": "tc",
      "coefficient": 11.853,
      "feature": 4.867534450455582,
      "product": 57.69488584125001
    },
    {
      "name": "ageTc",
      "coefficient": -2.664,
      "feature": 17.955747826477367,
      "product": -47.83411220973571
    },
    {
      "name": "hdl",
      "coefficient": -7.99,
      "feature": 4.605170185988092,
      "product": -36.795309786044854
    },
    {
      "name": "ageHdl",
      "coefficient": 1.769,
      "feature": 16.987917681789526,
      "product": 30.05162637908567
    },
    {
      "name": "sbpT",
      "coefficient": 1.797,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.764,
      "feature": 4.499809670330265,
      "product": 7.937664258462587
    },
    {
      "name": "smoke",
      "coefficient": 7.837,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.795,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.658,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 8

reference-008

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic White person
Age: 79 years
Total cholesterol: 320 mg/dL
HDL cholesterol: 20 mg/dL
Systolic blood pressure: 200 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicWhite",
  "ageYears": 79,
  "totalCholesterolMgDl": 320,
  "hdlCholesterolMgDl": 20,
  "systolicBpMmHg": 200,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 92.71522918124465
}

Actual result

{
  "linearPredictor": 64.5565993093616,
  "meanPredictorSum": 61.18,
  "baselineSurvival": 0.9144,
  "centeredPredictor": 3.376599309361602,
  "relativeHazard": 29.271059846601716,
  "survivalLog": -2.6193842061692774,
  "tenYearProbability": 0.9271522918124454,
  "tenYearPercent": 92.71522918124454,
  "terms": [
    {
      "name": "age",
      "coefficient": 12.344,
      "feature": 4.3694478524670215,
      "product": 53.93646429085291
    },
    {
      "name": "tc",
      "coefficient": 11.853,
      "feature": 5.768320995793772,
      "product": 68.37190876314358
    },
    {
      "name": "ageTc",
      "coefficient": -2.664,
      "feature": 25.204377787411527,
      "product": -67.14446242566432
    },
    {
      "name": "hdl",
      "coefficient": -7.99,
      "feature": 2.995732273553991,
      "product": -23.935900865696386
    },
    {
      "name": "ageHdl",
      "coefficient": 1.769,
      "feature": 13.089695949246632,
      "product": 23.15567213421729
    },
    {
      "name": "sbpT",
      "coefficient": 1.797,
      "feature": 5.298317366548036,
      "product": 9.52107630768682
    },
    {
      "name": "sbpU",
      "coefficient": 1.764,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 7.837,
      "feature": 1,
      "product": 7.837
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.795,
      "feature": 4.3694478524670215,
      "product": -7.843158895178303
    },
    {
      "name": "diabetes",
      "coefficient": 0.658,
      "feature": 1,
      "product": 0.658
    }
  ]
}

Case 9

reference-009

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic White person
Age: 53.25 years
Total cholesterol: 197.5 mg/dL
HDL cholesterol: 42.5 mg/dL
Systolic blood pressure: 137.25 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicWhite",
  "ageYears": 53.25,
  "totalCholesterolMgDl": 197.5,
  "hdlCholesterolMgDl": 42.5,
  "systolicBpMmHg": 137.25,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 13.97317213396266
}

Actual result

{
  "linearPredictor": 61.699940857242645,
  "meanPredictorSum": 61.18,
  "baselineSurvival": 0.9144,
  "centeredPredictor": 0.5199408572426449,
  "relativeHazard": 1.6819281728874311,
  "survivalLog": -0.15051098645080205,
  "tenYearProbability": 0.1397317213396252,
  "tenYearPercent": 13.97317213396252,
  "terms": [
    {
      "name": "age",
      "coefficient": 12.344,
      "feature": 3.9749978045895347,
      "product": 49.06737289985321
    },
    {
      "name": "tc",
      "coefficient": 11.853,
      "feature": 5.285738584341177,
      "product": 62.65185944019596
    },
    {
      "name": "ageTc",
      "coefficient": -2.664,
      "feature": 21.01079926839037,
      "product": -55.97276925099195
    },
    {
      "name": "hdl",
      "coefficient": -7.99,
      "feature": 3.7495040759303713,
      "product": -29.958537566683667
    },
    {
      "name": "ageHdl",
      "coefficient": 1.769,
      "feature": 14.904270470122738,
      "product": 26.36565446164712
    },
    {
      "name": "sbpT",
      "coefficient": 1.797,
      "feature": 4.92180408038964,
      "product": 8.844481932460182
    },
    {
      "name": "sbpU",
      "coefficient": 1.764,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 7.837,
      "feature": 1,
      "product": 7.837
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.795,
      "feature": 3.9749978045895347,
      "product": -7.135121059238214
    },
    {
      "name": "diabetes",
      "coefficient": 0.658,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 10

reference-010

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic White person
Age: 68 years
Total cholesterol: 245 mg/dL
HDL cholesterol: 36 mg/dL
Systolic blood pressure: 162 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicWhite",
  "ageYears": 68,
  "totalCholesterolMgDl": 245,
  "hdlCholesterolMgDl": 36,
  "systolicBpMmHg": 162,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 49.143687439623456
}

Actual result

{
  "linearPredictor": 63.20234328111665,
  "meanPredictorSum": 61.18,
  "baselineSurvival": 0.9144,
  "centeredPredictor": 2.0223432811166475,
  "relativeHazard": 7.556010060649815,
  "survivalLog": -0.6761659303846523,
  "tenYearProbability": 0.4914368743962319,
  "tenYearPercent": 49.14368743962319,
  "terms": [
    {
      "name": "age",
      "coefficient": 12.344,
      "feature": 4.219507705176107,
      "product": 52.08560311269386
    },
    {
      "name": "tc",
      "coefficient": 11.853,
      "feature": 5.501258210544727,
      "product": 65.20641356958666
    },
    {
      "name": "ageTc",
      "coefficient": -2.664,
      "feature": 23.2126014075568,
      "product": -61.83837014973132
    },
    {
      "name": "hdl",
      "coefficient": -7.99,
      "feature": 3.58351893845611,
      "product": -28.63231631826432
    },
    {
      "name": "ageHdl",
      "coefficient": 1.769,
      "feature": 15.120685772460059,
      "product": 26.74849313148184
    },
    {
      "name": "sbpT",
      "coefficient": 1.797,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.764,
      "feature": 5.087596335232384,
      "product": 8.974519935349925
    },
    {
      "name": "smoke",
      "coefficient": 7.837,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSmoke",
      "coefficient": -1.795,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.658,
      "feature": 1,
      "product": 0.658
    }
  ]
}

Case 11

reference-011

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic African-American person
Age: 55 years
Total cholesterol: 213 mg/dL
HDL cholesterol: 50 mg/dL
Systolic blood pressure: 120 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 55,
  "totalCholesterolMgDl": 213,
  "hdlCholesterolMgDl": 50,
  "systolicBpMmHg": 120,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 3.026329344319297
}

Actual result

{
  "linearPredictor": 86.1676998549622,
  "meanPredictorSum": 86.61,
  "baselineSurvival": 0.9533,
  "centeredPredictor": -0.44230014503780524,
  "relativeHazard": 0.642556746290709,
  "survivalLog": -0.030730680869647385,
  "tenYearProbability": 0.030263293443192535,
  "tenYearPercent": 3.0263293443192536,
  "terms": [
    {
      "name": "age",
      "coefficient": 17.114,
      "feature": 4.007333185232471,
      "product": 68.58150013206851
    },
    {
      "name": "tc",
      "coefficient": 0.94,
      "feature": 5.3612921657094255,
      "product": 5.03961463576686
    },
    {
      "name": "hdl",
      "coefficient": -18.92,
      "feature": 3.912023005428146,
      "product": -74.01547526270053
    },
    {
      "name": "ageHdl",
      "coefficient": 4.475,
      "feature": 15.676779611045077,
      "product": 70.15358875942671
    },
    {
      "name": "sbpT",
      "coefficient": 29.291,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSbpT",
      "coefficient": -6.432,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 27.82,
      "feature": 4.787491742782046,
      "product": 133.1880202841965
    },
    {
      "name": "ageSbpU",
      "coefficient": -6.087,
      "feature": 19.18507453487693,
      "product": -116.77954869379586
    },
    {
      "name": "smoke",
      "coefficient": 0.691,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.874,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 12

reference-012

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic African-American person
Age: 40 years
Total cholesterol: 130 mg/dL
HDL cholesterol: 100 mg/dL
Systolic blood pressure: 90 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 40,
  "totalCholesterolMgDl": 130,
  "hdlCholesterolMgDl": 100,
  "systolicBpMmHg": 90,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 0.013541761872041176
}

Actual result

{
  "linearPredictor": 80.74311423170191,
  "meanPredictorSum": 86.61,
  "baselineSurvival": 0.9533,
  "centeredPredictor": -5.86688576829809,
  "relativeHazard": 0.002831678118596184,
  "survivalLog": -0.00013542678851397982,
  "tenYearProbability": 0.0001354176187204061,
  "tenYearPercent": 0.013541761872040611,
  "terms": [
    {
      "name": "age",
      "coefficient": 17.114,
      "feature": 3.6888794541139363,
      "product": 63.13148297770591
    },
    {
      "name": "tc",
      "coefficient": 0.94,
      "feature": 4.867534450455582,
      "product": 4.575482383428247
    },
    {
      "name": "hdl",
      "coefficient": -18.92,
      "feature": 4.605170185988092,
      "product": -87.12981991889471
    },
    {
      "name": "ageHdl",
      "coefficient": 4.475,
      "feature": 16.987917681789526,
      "product": 76.02093162600812
    },
    {
      "name": "sbpT",
      "coefficient": 29.291,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSbpT",
      "coefficient": -6.432,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 27.82,
      "feature": 4.499809670330265,
      "product": 125.18470502858797
    },
    {
      "name": "ageSbpU",
      "coefficient": -6.087,
      "feature": 16.59925544030452,
      "product": -101.03966786513362
    },
    {
      "name": "smoke",
      "coefficient": 0.691,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.874,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 13

reference-013

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic African-American person
Age: 79 years
Total cholesterol: 320 mg/dL
HDL cholesterol: 20 mg/dL
Systolic blood pressure: 200 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 79,
  "totalCholesterolMgDl": 320,
  "hdlCholesterolMgDl": 20,
  "systolicBpMmHg": 200,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 74.08866091261832
}

Actual result

{
  "linearPredictor": 89.95066072862288,
  "meanPredictorSum": 86.61,
  "baselineSurvival": 0.9533,
  "centeredPredictor": 3.340660728622879,
  "relativeHazard": 28.237778051195995,
  "survivalLog": -1.3504895104885228,
  "tenYearProbability": 0.7408866091261666,
  "tenYearPercent": 74.08866091261666,
  "terms": [
    {
      "name": "age",
      "coefficient": 17.114,
      "feature": 4.3694478524670215,
      "product": 74.7787305471206
    },
    {
      "name": "tc",
      "coefficient": 0.94,
      "feature": 5.768320995793772,
      "product": 5.422221736046145
    },
    {
      "name": "hdl",
      "coefficient": -18.92,
      "feature": 2.995732273553991,
      "product": -56.67925461564151
    },
    {
      "name": "ageHdl",
      "coefficient": 4.475,
      "feature": 13.089695949246632,
      "product": 58.57638937287867
    },
    {
      "name": "sbpT",
      "coefficient": 29.291,
      "feature": 5.298317366548036,
      "product": 155.19301398355853
    },
    {
      "name": "ageSbpT",
      "coefficient": -6.432,
      "feature": 23.150721438952043,
      "product": -148.90544029533956
    },
    {
      "name": "sbpU",
      "coefficient": 27.82,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSbpU",
      "coefficient": -6.087,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 0.691,
      "feature": 1,
      "product": 0.691
    },
    {
      "name": "diabetes",
      "coefficient": 0.874,
      "feature": 1,
      "product": 0.874
    }
  ]
}

Case 14

reference-014

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic African-American person
Age: 53.25 years
Total cholesterol: 197.5 mg/dL
HDL cholesterol: 42.5 mg/dL
Systolic blood pressure: 137.25 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 53.25,
  "totalCholesterolMgDl": 197.5,
  "hdlCholesterolMgDl": 42.5,
  "systolicBpMmHg": 137.25,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 14.170063769070726
}

Actual result

{
  "linearPredictor": 87.7715834689829,
  "meanPredictorSum": 86.61,
  "baselineSurvival": 0.9533,
  "centeredPredictor": 1.1615834689828972,
  "relativeHazard": 3.194988437806031,
  "survivalLog": -0.15280233322771675,
  "tenYearProbability": 0.14170063769070293,
  "tenYearPercent": 14.170063769070293,
  "terms": [
    {
      "name": "age",
      "coefficient": 17.114,
      "feature": 3.9749978045895347,
      "product": 68.0281124277453
    },
    {
      "name": "tc",
      "coefficient": 0.94,
      "feature": 5.285738584341177,
      "product": 4.968594269280706
    },
    {
      "name": "hdl",
      "coefficient": -18.92,
      "feature": 3.7495040759303713,
      "product": -70.94061711660262
    },
    {
      "name": "ageHdl",
      "coefficient": 4.475,
      "feature": 14.904270470122738,
      "product": 66.69661035379924
    },
    {
      "name": "sbpT",
      "coefficient": 29.291,
      "feature": 4.92180408038964,
      "product": 144.16456331869293
    },
    {
      "name": "ageSbpT",
      "coefficient": -6.432,
      "feature": 19.564160414168633,
      "product": -125.83667978393265
    },
    {
      "name": "sbpU",
      "coefficient": 27.82,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSbpU",
      "coefficient": -6.087,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 0.691,
      "feature": 1,
      "product": 0.691
    },
    {
      "name": "diabetes",
      "coefficient": 0.874,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 15

reference-015

Inputs

Sex in the published equation: Female
Derivation population group: Non-Hispanic African-American person
Age: 68 years
Total cholesterol: 245 mg/dL
HDL cholesterol: 36 mg/dL
Systolic blood pressure: 162 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "female",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 68,
  "totalCholesterolMgDl": 245,
  "hdlCholesterolMgDl": 36,
  "systolicBpMmHg": 162,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 40.32688703677115
}

Actual result

{
  "linearPredictor": 88.98910430404895,
  "meanPredictorSum": 86.61,
  "baselineSurvival": 0.9533,
  "centeredPredictor": 2.3791043040489512,
  "relativeHazard": 10.79522928912219,
  "survivalLog": -0.5162886361613184,
  "tenYearProbability": 0.40326887036771386,
  "tenYearPercent": 40.32688703677139,
  "terms": [
    {
      "name": "age",
      "coefficient": 17.114,
      "feature": 4.219507705176107,
      "product": 72.2126548663839
    },
    {
      "name": "tc",
      "coefficient": 0.94,
      "feature": 5.501258210544727,
      "product": 5.1711827179120435
    },
    {
      "name": "hdl",
      "coefficient": -18.92,
      "feature": 3.58351893845611,
      "product": -67.8001783155896
    },
    {
      "name": "ageHdl",
      "coefficient": 4.475,
      "feature": 15.120685772460059,
      "product": 67.66506883175876
    },
    {
      "name": "sbpT",
      "coefficient": 29.291,
      "feature": 0,
      "product": 0
    },
    {
      "name": "ageSbpT",
      "coefficient": -6.432,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 27.82,
      "feature": 5.087596335232384,
      "product": 141.5369300461649
    },
    {
      "name": "ageSbpU",
      "coefficient": -6.087,
      "feature": 21.467151937338766,
      "product": -130.67055384258106
    },
    {
      "name": "smoke",
      "coefficient": 0.691,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.874,
      "feature": 1,
      "product": 0.874
    }
  ]
}

Case 16

reference-016

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic African-American person
Age: 55 years
Total cholesterol: 213 mg/dL
HDL cholesterol: 50 mg/dL
Systolic blood pressure: 120 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 55,
  "totalCholesterolMgDl": 213,
  "hdlCholesterolMgDl": 50,
  "systolicBpMmHg": 120,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 6.0734372944925274
}

Actual result

{
  "linearPredictor": 18.9727973684095,
  "meanPredictorSum": 19.54,
  "baselineSurvival": 0.8954,
  "centeredPredictor": -0.5672026315905008,
  "relativeHazard": 0.5671096364558379,
  "survivalLog": -0.06265695686494871,
  "tenYearProbability": 0.0607343729449254,
  "tenYearPercent": 6.07343729449254,
  "terms": [
    {
      "name": "age",
      "coefficient": 2.469,
      "feature": 4.007333185232471,
      "product": 9.89410563433897
    },
    {
      "name": "tc",
      "coefficient": 0.302,
      "feature": 5.3612921657094255,
      "product": 1.6191102340442465
    },
    {
      "name": "hdl",
      "coefficient": -0.307,
      "feature": 3.912023005428146,
      "product": -1.2009910626664408
    },
    {
      "name": "sbpT",
      "coefficient": 1.916,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.809,
      "feature": 4.787491742782046,
      "product": 8.660572562692721
    },
    {
      "name": "smoke",
      "coefficient": 0.549,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.645,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 17

reference-017

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic African-American person
Age: 40 years
Total cholesterol: 130 mg/dL
HDL cholesterol: 100 mg/dL
Systolic blood pressure: 90 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 40,
  "totalCholesterolMgDl": 130,
  "hdlCholesterolMgDl": 100,
  "systolicBpMmHg": 90,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 1.1742145762901328
}

Actual result

{
  "linearPredictor": 17.304207222773996,
  "meanPredictorSum": 19.54,
  "baselineSurvival": 0.8954,
  "centeredPredictor": -2.2357927772260027,
  "relativeHazard": 0.10690734254237061,
  "survivalLog": -0.011811629215271213,
  "tenYearProbability": 0.011742145762901298,
  "tenYearPercent": 1.17421457629013,
  "terms": [
    {
      "name": "age",
      "coefficient": 2.469,
      "feature": 3.6888794541139363,
      "product": 9.107843372207308
    },
    {
      "name": "tc",
      "coefficient": 0.302,
      "feature": 4.867534450455582,
      "product": 1.4699954040375858
    },
    {
      "name": "hdl",
      "coefficient": -0.307,
      "feature": 4.605170185988092,
      "product": -1.4137872470983441
    },
    {
      "name": "sbpT",
      "coefficient": 1.916,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.809,
      "feature": 4.499809670330265,
      "product": 8.140155693627449
    },
    {
      "name": "smoke",
      "coefficient": 0.549,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.645,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 18

reference-018

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic African-American person
Age: 79 years
Total cholesterol: 320 mg/dL
HDL cholesterol: 20 mg/dL
Systolic blood pressure: 200 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 79,
  "totalCholesterolMgDl": 320,
  "hdlCholesterolMgDl": 20,
  "systolicBpMmHg": 200,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 96.54123982745598
}

Actual result

{
  "linearPredictor": 22.956085954795757,
  "meanPredictorSum": 19.54,
  "baselineSurvival": 0.8954,
  "centeredPredictor": 3.416085954795758,
  "relativeHazard": 30.44999880148351,
  "survivalLog": -3.3642599927692554,
  "tenYearProbability": 0.9654123982745598,
  "tenYearPercent": 96.54123982745598,
  "terms": [
    {
      "name": "age",
      "coefficient": 2.469,
      "feature": 4.3694478524670215,
      "product": 10.788166747741075
    },
    {
      "name": "tc",
      "coefficient": 0.302,
      "feature": 5.768320995793772,
      "product": 1.742032940729719
    },
    {
      "name": "hdl",
      "coefficient": -0.307,
      "feature": 2.995732273553991,
      "product": -0.9196898079810751
    },
    {
      "name": "sbpT",
      "coefficient": 1.916,
      "feature": 5.298317366548036,
      "product": 10.151576074306037
    },
    {
      "name": "sbpU",
      "coefficient": 1.809,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 0.549,
      "feature": 1,
      "product": 0.549
    },
    {
      "name": "diabetes",
      "coefficient": 0.645,
      "feature": 1,
      "product": 0.645
    }
  ]
}

Case 19

reference-019

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic African-American person
Age: 53.25 years
Total cholesterol: 197.5 mg/dL
HDL cholesterol: 42.5 mg/dL
Systolic blood pressure: 137.25 mmHg
Current antihypertensive treatment?: Yes
Current smoking?: Yes
Diabetes?: No
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 53.25,
  "totalCholesterolMgDl": 197.5,
  "hdlCholesterolMgDl": 42.5,
  "systolicBpMmHg": 137.25,
  "treatedBp": "yes",
  "smoker": "yes",
  "diabetes": "no",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 19.923430017126194
}

Actual result

{
  "linearPredictor": 20.23864149871852,
  "meanPredictorSum": 19.54,
  "baselineSurvival": 0.8954,
  "centeredPredictor": 0.6986414987185192,
  "relativeHazard": 2.011018879211835,
  "survivalLog": -0.22218688428015398,
  "tenYearProbability": 0.19923430017126145,
  "tenYearPercent": 19.923430017126144,
  "terms": [
    {
      "name": "age",
      "coefficient": 2.469,
      "feature": 3.9749978045895347,
      "product": 9.81426957953156
    },
    {
      "name": "tc",
      "coefficient": 0.302,
      "feature": 5.285738584341177,
      "product": 1.5962930524710353
    },
    {
      "name": "hdl",
      "coefficient": -0.307,
      "feature": 3.7495040759303713,
      "product": -1.151097751310624
    },
    {
      "name": "sbpT",
      "coefficient": 1.916,
      "feature": 4.92180408038964,
      "product": 9.430176618026548
    },
    {
      "name": "sbpU",
      "coefficient": 1.809,
      "feature": 0,
      "product": 0
    },
    {
      "name": "smoke",
      "coefficient": 0.549,
      "feature": 1,
      "product": 0.549
    },
    {
      "name": "diabetes",
      "coefficient": 0.645,
      "feature": 0,
      "product": 0
    }
  ]
}

Case 20

reference-020

Inputs

Sex in the published equation: Male
Derivation population group: Non-Hispanic African-American person
Age: 68 years
Total cholesterol: 245 mg/dL
HDL cholesterol: 36 mg/dL
Systolic blood pressure: 162 mmHg
Current antihypertensive treatment?: No
Current smoking?: No
Diabetes?: Yes
Previous myocardial infarction?: No
Previous stroke?: No
Previous heart failure?: No
Previous percutaneous coronary intervention?: No
Previous coronary artery bypass surgery?: No
Previous atrial fibrillation?: No
Apparently healthy status at baseline assessment confirmed?: Yes
Use of the historical model for research confirmed?: Yes

{
  "sex": "male",
  "population": "nonHispanicAfricanAmerican",
  "ageYears": 68,
  "totalCholesterolMgDl": 245,
  "hdlCholesterolMgDl": 36,
  "systolicBpMmHg": 162,
  "treatedBp": "no",
  "smoker": "no",
  "diabetes": "yes",
  "priorMI": "no",
  "priorStroke": "no",
  "priorHF": "no",
  "priorPCI": "no",
  "priorCABG": "no",
  "atrialFibrillation": "no",
  "apparentlyHealthy": "yes",
  "historicalResearchConfirmed": "yes"
}

Expected result

{
  "tenYearPercent": 32.9969294153124
}

Actual result

{
  "linearPredictor": 20.82766595999367,
  "meanPredictorSum": 19.54,
  "baselineSurvival": 0.8954,
  "centeredPredictor": 1.2876659599936708,
  "relativeHazard": 3.6243173741463988,
  "survivalLog": -0.40043173802506704,
  "tenYearProbability": 0.3299692941531238,
  "tenYearPercent": 32.99692941531238,
  "terms": [
    {
      "name": "age",
      "coefficient": 2.469,
      "feature": 4.219507705176107,
      "product": 10.417964524079807
    },
    {
      "name": "tc",
      "coefficient": 0.302,
      "feature": 5.501258210544727,
      "product": 1.6613799795845077
    },
    {
      "name": "hdl",
      "coefficient": -0.307,
      "feature": 3.58351893845611,
      "product": -1.1001403141060258
    },
    {
      "name": "sbpT",
      "coefficient": 1.916,
      "feature": 0,
      "product": 0
    },
    {
      "name": "sbpU",
      "coefficient": 1.809,
      "feature": 5.087596335232384,
      "product": 9.203461770435382
    },
    {
      "name": "smoke",
      "coefficient": 0.549,
      "feature": 0,
      "product": 0
    },
    {
      "name": "diabetes",
      "coefficient": 0.645,
      "feature": 1,
      "product": 0.645
    }
  ]
}

Code and reproducibility

This tool’s code on GitHub

Download code and tests

Sources, version and reproduction instructions

The code tests are technical checks. Clinical approval and professional translation review are recorded separately.